American Cancer Society - no drinking allowed

TL;DR: “No drinking allowed” is a very broad and conservative statement. Based on conclusions of the underlying study, it appears that having 1 “standard” drink per day carries similar risk as not having any drinks.

American Cancer Society (ACS) just published their newly revised diet/exercise/etc guidelines on minimizing cancer risks. From a summary in Forbes:

Previous guideline from 2012: If you drink alcoholic beverages, limit to no more than 1 drink per day for women and 2 per day for men.

New: The ACS now says it’s best to completely avoid all alcohol. However, they say for people who do choose to drink. they repeat the previous recommendation of no more than 1 drink per day for women and 2 drinks per day for men.

The full recommendation is published as an article in a medical journal. An edited excerpt:

Alcohol consumption is the third major modifiable cancer risk factor after tobacco use and excess body weight.

In 2016, approximately 50.7% of the US population aged ≥12 years reported current (ie, in the past 30 days) alcohol consumption, approximately 6% were heavy alcohol drinkers (ie, drank ≥5 alcoholic beverages on the same occasion on ≥5 days in the past 30 days), and approximately 24.2% of the population were binge drinkers (ie, drank at least ≥5 alcoholic beverages on the same occasion on at least 1 day in the past 30 days).

Despite the fact that a substantial number of cancer cases are attributed to alcohol consumption in the United States, and that reducing alcoholic beverage consumption is one of the WHO Best Buys for reducing noncommunicable diseases, public awareness about the carcinogenicity of alcohol, and its primary metabolite acetaldehyde, is low. Furthermore, fewer than one‐half of the CDC‐funded comprehensive cancer control plans specify goals, objectives, or strategies for alcohol control. Finally, alcohol control has benefits beyond those for cancer, and recently a report from the Global Burden of Disease Study found that “consuming zero standard drinks daily minimizes the overall risk to health"

It appears that the change in guideline from 1/2 drinks per day to 0 drinks is based on a study from 2016 performed by the Institute for Health Metrics and Evaluation (IHME), a global health research center at the University of Washington (US). IHME is in the business of evidence-based healthcare, they’re funded in large part by Bill and Melinda Gates Foundation. Evidence-based healthcare is making conclusions based on data. Collecting massive amounts of data, untangling it, removing or factoring for bias, dealing with various other data issues is the nature of their work. They don’t perform experiments of, say, making people imbibe various amounts of alcohol and then tracking their health.

The study looked at alcohol use in 195 countries and territories for the period of 1990–2016. They went through a large spectrum of humans, ranging in age from 15 to 95+. That is a lot of data and at truly global scale but it’s also a lot of factors. Common sense would dictate that someone who drinks copious amounts at 20 years of age is more likely to die from a road accident rather than cancer. The full text of the study confirms this. The older folks have a different story:

For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27.1% of total alcohol-attributable female deaths and 18.9% of male deaths. The level of alcohol consumption that minimized harm across health outcomes was zero standard drinks per week.

This conclusive last sentence has a very curious wording, “minimized harm across health outcomes”. Remember all that stuff you’ve heard about how a glass of red a day helps you lower the risk of heart disease, wouldn’t that be “minimizing harm”? They took that into account:

In estimating the weighted relative risk curve, we found that consuming zero standard drinks daily minimized the overall risk of all health loss The risk rose monotonically with increasing amounts of daily drinking. This weighted relative risk curve took into account the protective effects of alcohol use associated with ischemic heart disease and diabetes in females. However, these protective effects were offset by the risks associated with cancers, which increased monotonically with consumption. > In a sensitivity analysis, where we explored how the weighted relative risk curve changed on the basis of the choice of weights for various health outcomes, the curve changed significantly only in settings where diabetes and ischemic heart disease comprised more than 60% of total deaths in a population> .

Wait, what? Are they now saying that for a (presumably older) group where diabetes+heart disease are causing more deaths versus the rest of the population, it might help to drink more than zero glasses per day?! Their choice of words is almost deliberately oblique. Let’s have a look at their graph that shows risk versus number of drinks:

Color me purple and call me Barney, 0 drinks and 1 drink appear to yield the same risk! If you think this is an optical illusion, have a look at the hi-res version of the graph. Without diving into their data, I can’t say if the 0 versus 1 line is truly straight and the risk is indeed the same…but it certainly looks that way. Someone call Forbes.

Last but not least, ACS and IHME study appear to be using a different definition of a “standard” drink.

IHME: Standard drink is 10 grams of pure alcohol. About the equivalent of:

A small glass of red wine (100 ml or 3.4 fluid ounces) at 13% alcohol by volume;
A can or bottle of beer (375 ml or 12 fluid ounces) at 3.5% alcohol by volume; or
A shot of whiskey or other spirits (30 ml or 1.0 fluid ounces) at 40% alcohol by volume.
“Standard drinks” are different by country. For example, in the UK a standard drink is 8 grams of alcohol, whereas in Australia, the US, and Japan, it is 10 grams.

ACS: Standard drink is 12 ounces of regular beer, 5 ounces of wine, or 1.5 ounces of 80-proof distilled spirits. 5 ounces of wine at 12-13% is 14 grams of pure alcohol.

I guess I’m going to die. Who isn’t?

This is somewhat scary to see, but hard to say that I’ll change my behavior based on it. Obviously I think we all somewhat know and accept that alcohol, including our beloved wine, is not a healthy hobby. I’ve chosen to accept this risk, and limit my wine consumption to a few days a week. I’m okay with a bit of risk if it means a life well lived.

IHME keeps getting their coronavirus projections way wrong. I’ll take my chances.

“it appears that having 1 “standard” drink per day carries similar risk as not having any drinks”.

That is why I never have just 1 drink a day!

Preliminary projections about a virus known to mankind for all of five months help you draw conclusions about decades worth of data across wide swaths of the worlds population on cancer?

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If one’s overriding goal in life were simply to live as many years as possible, wine would be on a very long list of substances and activities one would never do.

If, on the other hand, you wanted the most joy and happiness in life …

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Long boring life vs. there is a chance you won’t live as long but enjoy it. I’ll take the latter. You could also die in a car crash. Drink in moderation and enjoy your friends and family.

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Roughly 38% of the US population will eventually be diagnosed with cancer. If we round that up to 40% and for the sake of discussion assume that is the 0 drink baseline, I real the graph to indicate that 2 drinks per day raises that ~10% to 44% and 3 drinks per day raises it ~25% to 50% disregarding the confidence bands. I would really love a more detailed graph at the lower end or a table.

But we know that the 38% includes more factors and the above analysis and that therefore the baseline from which these factors are applied is actually lower. If we assume that someone without genetic predisposition and other health factors is half of the above then 2 drinks per day (14 drinks per week) only raises your cancer risk from 20% to 22% and three drinks to 25%.

I have no idea if any of the above applies. I just always get annoyed at how data is published as to change in probability without consideration for the basis to which it should be applied. Obviously cancer is a severe problem and I like many have lost friends to it. I am not suggesting anyone should ignore the health impacts of alcohol or how it may change the risk of cancer.

Edited to add that based on the upper bound of the uncertainty at 15 drinks per day at over 4.5, the base to which this applies can be no higher than 22% and most likely lower as I doubt that the upper bound equates to 100% chance of cancer.

This makes sense to me, and while I certainly may be missing something, does that chart indicate that at fifteen drinks per day one’s risk (shown by the"mean"(?) curve) is 3 times the base, so increased 200%?. I don’t think I know anybody who drinks at that level, but that risk estimate strikes me as hilariously low.

Just wait 10 years and the research will change.

I am (for now at least) a cancer survivor. My consulting oncologist did not even suggest that I stop drinking. He said (three weeks ago) weight control is by far the most important thing, and pretty much everything else (other than tobacco use - I don’t) is “very minor” (his words) in comparison.

We all know alcohol is bad for us, as are: preserved meats, charred meats, plasticizers in our products, pesticides, the thousands of ‘forever chemicals’ per- and poly-fluoroalkyl substances, mercury in fish and water, lead in old water pipes and homes, gasoline and diesel emissions…

The questions is: what’s gonna kill us? And we honestly don’t know. But probably best to limit your exposure to anything that is a known bad goes without saying.

This is interesting to hear and makes sense to me. Obesity and metabolic syndrome seem to be the real drivers of almost all disease these days.

There are certainly better and worse choices on can make. Personally, I think of it in terms of what I call “poison load.” We all consume things that can be considered poisons (not talking here about the things we can’t really control, like air quality). Alcohol is one of them. I also think sugar, soda, highly processed foods, trans fat, refined flour, and industrial seed oils, among other things, are poisons. Not all poisons are created equal, of course, but to keep things simple and life in balance and enjoyable, I try and control my overall poison load. I consume more alcohol than most people. I consume far, far less of those other poisons than most people. At least so far, my modest weight and robust good health seem to be positive signs.

Wait 6 weeks and the research will change. You mean if I stop drinking completely I’ll get to live another 3-6 months? (on average). I don’t know why anyone pays attention to this ridiculous back and forth anymore. Humans biologically are programmed to live to about 4 score years, give or take. Excuse me I have to go and eat my scrambled eggs now…

There is a school of thought that says that to deprive one of something they enjoy in healthy moderation is to create a stress in the mind and therefore the body that can lead to cancer.

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Cris, the way it works is if you’re wrong once then you’re always wrong. You don’t get to be right ever again.

Moderation is key for alcohol consumption, just like everything else. Could you die from having a glass per day? Sure. Will you die from having 10 glasses per day? Probably. That same logic applies to cheeseburgers, stress in your life, and so on. Just be moderate, you’ll get some enjoyment and you probably aren’t going to kill yourself. Or at least not all that much quicker than you would normally have died.

I look forward to all the extremely defensive replies

Including your passive-aggressive reply here?

Nothing all that passive about it