Stay nearby and go early or late.
i’ve stayed twice at the savoy on the piazza republica.
one block from the duomo and overlooking cafe gilli
to wake up and open the wooden shutters to listen to a live performance of mio babbino caro didn’t suck either!
highly recc’d and (i believe) still in the amex platinum group
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We loved our rooms at the St. Regis, the amazing frescoes in our room and views of the Arno. Our favorite was to stroll across the Ponte Vecchio at night without the crowds.
Many years ago when we were looking for less crowds, we stayed at Hotel Regency. I’d check current review for that one. Easy walks to most things but outside of the main tourist areas for less crowding.
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This. We’ve used VRBO twice in Florence and Rome. Balconies, kitchens, living rooms. Easy to get the area you want. Great if you are there 4-5 nights.